Synthetic Organic CheM–Lab | Concise Synthesis & Selective Transformations
We study selective bond activation & functionalization for molecular complexity
I. Metal-catalyzed selective transformations and/or functionalizations of pi systems
: synthetic routes and mechanistic studies on the reactivity and selectivity patterns
: selective difunctionalization/(cyclo)addition of unsymmetrical alkynes or olefines
II. Directed/nondirected C–H arylation of (hetero)arenes using hypervalent compounds
: two- or four-fold C–H arylation approaches of (hetro)arenes using iodonium salts
: palladium-catalyzed and metal-free C–H arylation events to access (doped-)PAHs
III. Oxidation-state modulation to access active radical species or to activate inert bonds
: redox chemistry assisted activation of organic, organometallic and catalytic species
Key publications:
Org. Lett. 2019, 21, 7004-7008; nondirected Pd-catalyzed C–H arylation
J. Org. Chem. 2019, 84, 6737-6751; chemoselective modifications of quinazolinones
J. Am. Chem. Soc. 2017, 139, 12121-12124; Ni-catalyzed azide–alkyne cycloaddition
Angew. Chem. Int. Ed. 2017, 56, 5007-5011; triphenylene synthesis through C–H arylation
Chem. Commun. 2017, 53, 10394-10397; late-stage modifications of quinazolinones
Bioconjugate. Chem. 2016, 27, 2007-2013; modified imidazoquinonline-nanoparticles
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The Hong Lab | Prof. Sung You Hong | Ulsan National Institute of Science and Technology (UNIST)
email: syhong@unist.ac.kr