Transformation of simple systems into value-added structures: Ni catalysis and SuFEx chemistry

Our research goal is to develop synthetic methods based on the understanding of reactivities of catalytic manifolds.
We investigate metal catalyzed inert bond activation, annulation, cycloaddition and hydrofunctionalization reactions.




Nickel catalysis: reactivity study, mechanistic study & identification of catalytic species
JACS Au 2024, ASAP: Ni-catalyzed borylation of aryl fluorosulfates, identification of nickel(II) species
J. Org. Chem. 2021, 86, 9328; Ni-catalyzed [2+2+2] cycloaddition to access multi-substituted pyridines
J. Am. Chem. Soc. 2017, 139, 12121; NiAAC click chemistry to selectively access 1,5-disubstituted triazoles


SuFEx chemistry: synthesis and applications of organosulfurs and studies on synthetic methods
Org. Lett. 2021, 23, 2766; synthetic approach to 18F-labelled sulfamoyl fluorides via isotope exchange
Org. Lett. 2020, 22, 5511; nucleophilic fluorination of aryl imidazylates and synthesis of aryl fluorosulfates


Annulative approaches for fused cyclic structures via metal catalysis or bond activation
Nat. Commun. 2022, 13, 2421; base-promoted Minisci-type annulation of simple azines
Org. Lett. 2019, 21, 7004; annulation of arenes via nondirected electrophilic C–H activation
Angew. Chem. Int. Ed. 2017, 56, 5007; annulative approach for triphenylenes via C–H arylation